CURRICULUM
VITAE CURRICULUM
VITAE
NAME: Frank William Sellke
ADDRESS: Beth Israel Deaconess Medical Center
Division of Cardiothoracic Surgery
110 Francis Street, LMOB 2A
Boston, MA 02215
617-632-8383
fax: 617-632-8387
email: fsellke@caregroup.harvard.edu
PLACE OF BIRTH: Fort Wayne, Indiana
EDUCATION AND TRAINING:
Education:
1978 A. B. Wabash College (Crawfordsville, IN)
1981 M. D. Indiana University School of Medicine (Indianapolis, IN)
2000 M.A. (Honorary) Harvard University (Cambridge, MA)
Postdoctoral Training:
Internship and Residencies:
1981-1982 Intern, Surgery, Indiana University Hospital, Indianapolis
1982-1986 Resident, General Surgery, Akron City Hospital, Northeastern Ohio
Universities College of Medicine, Akron
1986-1987 Chief Resident, Surgery, Akron City Hospital, Northeastern Ohio
Universities College of Medicine, Akron
1987-1990 Chief Resident, Thoracic and Cardiovascular Surgery
University of Iowa Hospitals and Clinics, Iowa City
Research Fellowship:
1988-1989 Research Fellow, Vascular Physiology
Cardiovascular Center, University of Iowa College of Medicine, Iowa
Licensure and Certification:
1981 Indiana Medical License
1988 American Board of Surgery
Recertified 1995
1989 Iowa Medical License
1990 Massachusetts Medical License
1991 American Board of Thoracic Surgery
Recertified 1999
PROFESSIONAL APPOINTMENTS:
Academic Appointments:
1987-1990 Fellow Associate in Cardiothoracic Surgery, University of Iowa
College of Medicine
1990-1993 Instructor in Surgery, Harvard Medical School
1993-1995 Assistant Professor of Surgery, Harvard Medical School
1995- 2000 Associate Professor of Surgery, Harvard Medical School
2000- Professor of Surgery, Harvard Medical School
Hospital Appointments:
1990-1996 Associate in Cardiothoracic Surgery, Beth
Israel Hospital, Boston
1990-1996 Clinical Associate in Surgery, Massachusetts General Hospital, Boston
1994-1996 Active Staff (Cardiothoracic Surgery), Deaconess Hospital, Boston
1996- Active Staff, (Cardiothoracic Surgery),
Beth Israel-Deaconess Medical Center, Boston
1999- Interim Chief, Division of Cardiothoracic Surgery
Beth Israel Deaconess Medical Center, Boston
2000- Interim Chief (Cardiac Surgery), Landmark Medical Center, Woonsocket RI
Other Professional Positions, Major Visiting Appointments:
1994 Ad hoc Reviewer: Merit Grant, Veteran's Administration, Spring and Fall
1994 Ad hoc Reviewer: Long-term Research Grant,
International Science Foundation
1999 Visiting Professor in Anesthesiology Research,
Johns Hopkins Hospital,
Baltimore
1995 Visiting Professor, Dunedin Hospital, Dunedin, New Zealand
1995-1999 Ad hoc Reviewer: Merit Grant, Veteran's
Administration, Spring '95 &
Fall '96, Summer '99
1997 Ad hoc Reviewer: National Institutes of Health,
Division of Research Grants
Surgical-Bio-Engineering Study Section.
1997-98 Safety Monitoring Officer. "Delivery
system for transmyocardial
revascularization by Xenon chloride excimer laser" US Surgical Corp.
1998-00 Abstract grader: American Heart Association Scientific Sessions.
1998 Visiting Professor, University of Iowa College of Medicine, Iowa City
1998-99 Abstract grader: Society of University Surgeons Residents' Program
1998 Ad hoc Reviewer: National Institutes of Health,
Division of Research Grants, February
Surgery, Trauma, Anesthesiology Study Section.
1999 Visiting Professor, University of Sao Paulo, Brazil
1999 Visiting Professor, University of Brazilia, Brazil
1999 Safety Monitoring Officer: High risk registry
of localized radiation therapy
to inhibit restenosis after stenting (protocol #P98-5502)
1999 Visiting Professor, Carolinas Heart Institute, Charlotte, NC
1999 Ad hoc Reviewer: National Institutes of Health,
Division of Research Grants, October
Surgery, Trauma, Anesthesiology Study Section.
1999 Ad hoc Reviewer: National Institutes of Health,
Division of Research Grants
Special Study Section W (25).
1999 Ad hoc Reviewer, US Army Medical Research and Materials Command
2000 Ad hoc Reviewer: National Institutes of Health,
Division of Research Grants
Special Study Section
2000 Abstract Reviewer: European Society of Surgical Research Meeting
2000 Visiting Professor, Medical Physiology, Texas
A & M University,
College Station, TX
2000 Visiting Professor . Bethesda Trihealth Good Samaritan, Cincinnati, OH
2000 Abstract Grader, American College of Chest Physicians
2000-04 Full-time member: National Institutes of Health,
Division of Research Grants,
Surgery, Trauma, Anesthesiology Study Section.
MAJOR COMMITTEE ASSIGNMENTS:
Beth Israel Hospital/Beth Israel Deaconess Medical Center
1992-93 Member, Critical Care Committee
1994-96 Member, Planning Committee for Carl Shapiro Clinical Center
1994- Member, Animal Care and Use Committee
1994- Member, Trauma Research Advisory Committee
1994- Member, Anesthesia Research Advisory Committee
1998 Ad hoc Reviewer, BIDMC Investment Awards-Junior Investigator Award 1998-
Congestive Heart Failure Disease Management Program
1999- Cardiac Outreach Committee
2000- Co-chairman, Cardiology/Cardiac Surgery Clinical volume initiative
2000- Member, BIDMC/Joslin Joint Initiative for Cardiology
2001- BIDMC Contracts and Payments Committee
ADMINISTRATIVE RESPONSIBILITIES:
1992-97 Director of Cardiac Surgery Outpatient clinic,
BIH/BIDMC East Campus
1999- Interim Chief, Division of Cardiothoracic Surgery,
Beth Israel Deaconess Medical Center
PROFESSIONAL SOCIETY INVOLVEMENT:
1978- American Medical Association
1979-81 Member, Legislative Commission, Indiana State Medical Society
1983-90 American College of Surgeons, Candidate Group
1990-93 American College of Surgeons, Associate Fellow
1990- Massachusetts Medical Society
1990- Norfolk District Medical Society
1990- American Heart Association
1991- Member, Council on Circulation
1992- Fellow, Council on Circulation
1992- Council on Cardiothoracic and Vascular Surgery
1998 Team leader, Scientific Sessions Program Committee for Category 71-Myocardial
Protection and
Intra-operative Management
1999- Executive Committee, Council on Cardiothoracic and Vascular Surgery
1990- American Heart Association, Massachusetts Affiliate
1991- American Physiological Society
1991- Fellow, American College of Chest Physicians
1991- New England States Chapter A.C.C.P.
1992- Fellow, American College of Cardiology
1992- Association for Academic Surgery
1996-98 Membership Committee
1993- American Association for the Advancement of Science
1993- Massachusetts Chapter, American College of Cardiology
1994- Fellow, American College of Surgeons
1994- American College of Surgeons, Massachusetts Chapter
1995- Society of Thoracic Surgeons
1995- Society of University Surgeons
1998-2000 Chairman, Committee on Publications and
Program Chairman
1998-2000 Executive Council
1996- American Association for Thoracic Surgery
1995- Shock Society
1995- International Association for Cardiac Biological Implants
1995- Boston Surgical Society
1996- Surgical Biology Club-1, American College of Surgeons
1999- Cardiac Surgery Biology Club
1999- New England Surgical Society
1999- Thoracic Surgery Directors Association
2000- New England Surgical Society
2001- Massachusetts Society of Thoracic Surgeons
2001- Board of Directors
COMMUNITY SERVICE:
1996- Project Success for Minority High School Students.
National Institutes of Health funded educational grant, Joan Reede, MD, Program
Director, Mentor and supervisor to Sean Sealy (Summer 1996, Summer 1997, Summer
1998) and Vantrice Taylor (Summer 1999), Glenn Hall, Jr.
(summer 2000) (2-4 hours of instruction per week )
1998, 99 Medical Malpractice Tribunal, Middlesex County Superior Court
EDITORIAL BOARD:
1998-00 Member, Surgery
1999- Member, Journal of Thoracic and Cardiovascular Surgery
1999- Member, Basic Research in Cardiology
1999- Member, Internet Cardiothoracic Digest (AATS)
2001- Member, Journal of Surgical Research
Ad hoc Reviewer: Journal of Clinical Investigation
Annals of Thoracic Surgery
Journal of Thoracic and Cardiovascular Surgery
Circulation Research
Circulation
Circulation, Surgical Issue
Surgery
American Journal of Physiology, Heart and Circulatory Physiol.
American Journal of Physiology, Cell Physiology
Cardiovascular Research
Journal of Molecular and Cellular Cardiology
Intensive Care Medicine
Anesthesia and Analgesia
Anesthesiology
Chest
Microvascular Research
Basic Research in Cardiology
Transplantation
Journal of Surgical Research
Magnesium Research
Shock
British Journal of Pharmacology
Arteriosclerosis, Thrombosis, and Vascular Biology
Journal of Physiology
Clinical Science
Heart and Vessels
AWARDS AND HONORS:
1978 Phi Beta Kappa, Summa Cum Laude, Wabash College
1978 Comprehensive Final Examination in Chemistry, Pass with Distinction
1985 Cleveland Surgery Society Research Award, Second Place
1985 Ohio Chapter, American College of Surgeons Research Award,
Second Place
1992 Young Investigator Award, American Heart Association
1992-94 Physician-Scientist Award, American College of Chest Physicians
1993 Young Investigator Award, American Heart Association
PART II
Major Research Interests:
1. Coronary microvascular physiology and pharmacology.
2. Pathophysiologic consequences of cardiopulmonary bypass and cardioplegia.
3. Pulmonary microvascular physiology and pathology.
4. Ischemic myocardium and coronary circulation.
5. Altered vasomotor regulation of the coronary collateral circulation.
6. Therapeutic angiogenesis in patients with coronary artery disease.
7. Vasomotor effects of inhalation anesthetics.
8 Protein tyrosyl phosphorylation and vascular permeability
Description of Research:
My laboratory is involved primarily in the examination of the microcirculation
of the heart, lung, brain and other organs. Specifically, we investigate the
effects of extracorporeal circulation, cardioplegia, ischemia and reperfusion
on altered vasomotor regulation, permeability, and gene expressions of proteins
involved in vasomotor regulation and permeability. The use of pharmacologic
probes and inhibitors of complement, neutrophil activation and adherence, and
specific biochemical processes are used in large animal models of extracorporeal
circulation and cardioplegia. In addition, the in vitro examinations of isolated,
pressurized microvessels and other tissues are performed extensively. These
in vitro techniques allow us to determine mechanisms of altered vasomotor characteristics
of the coronary and peripheral microcirculation. Currently we are examining
microvascular alterations after cardioplegia and cardiopulmonary bypass with
respect to intracellular calcium handling, tyrosine kinase receptor phosphorylation,
protein kinase C isoform translocation and activity, phosphorylation of myosin
light chain, and changes in expression of isoforms of nitric oxide synthase
and other proteins contributing to vasomotor tone and permeability.
Another primary area of investigation is the use of angiogenic growth factor
proteins such as fibroblast growth factor-2 (FGF-2) and vascular endothelial
growth factor (VEGF) to increase blood flow to ischemic myocardium. Both acute
and chronic models of myocardial ischemia are used and intravascular and perivascular
growth factor are applied. This research in animal models has been extended
to a human clinical trial in which FGF-2 is administered by slow release devices
to the ischemic and borderline non-ischemic myocardium of patients who cannot
undergo standard coronary bypass surgery. Patients are evaluated clinically
with magnetic resonance imaging and standard radionucleotide perfusion studies
at intervals after implantation of the slow release devices.
Secondary areas of research interest include mechanisms of complement and neutrophil-induced
injury of the vascular endothelium, regulation of contraction and growth of
blood vessels, and magnetic resonance imaging of the porcine and human collateral
circulation. All of the above research is funded primarily by grants from the
National Institutes of Health and secondarily by industrial source funding.
Research Funding Information:
Past:
1988-89 NHLBI Institutional Research Grant Cardiovascular Center, University
of
Iowa College of Medicine, Iowa City.
1990-92 Beth Israel Hospital Start-up Grant "Cardioplegia
and Coronary
Microvascular Reactivity." [Principal Investigator].
1992-99 NIH T32 HL 07374 "Cardiovascular research
training program"
[Co-investigator]
1992-95 American Heart Association, Massachusetts
Affiliate Grant-In-Aid.
"Coronary Venous Microvascular Reactivity" 13-501-912.
[Principal Investigator].
1992-97 NIH First Award, "Cardioplegia and Coronary
Microvascular Reactivity"
R29 HL-46716. [Principal Investigator].
1996-97 Genentech, Inc. "VEGF in chronic Myocardial
Ischemia."
[Co-investigator].
1996-97 Chiron Corporation, "Intrapericardial
administration of basic FGF in
chronic myocardial ischemia. [Co-investigator].
1996-99 NIH RO1 HL31704. "Regulation of contraction and growth of blood vessels". [Co-investigator].
Present:
1997-01 NIH RO1 HL-46716, "Cardioplegia and
Coronary Microvascular Reactivity"
[Principal Investigator].
1995-04 NIH R01 HL53793. "Angiogenesis in Myocardial
Ischemia".
[Co-investigator].
1996-01 NIH 2T32 GM07806. "Academic Training
in Trauma and Burns."
[Co-investigator].
1997-02 NIH P50 HL 56993 SCOR Molecular Medicine. Section 6. Stimulation of
human coronary angiogenesis with basic FGF. [Co-investigator].
1998-00 NIH R01HL 58072. "Magnetic resonance
imaging of coronary collaterals".
[Co-investigator].
1999-03 NIH RO1 HL62289. "Syndecan function in endothelial cells". [Co-investigator].
2000-02 Genzyme, HIF-1a and coronary angiogenesis. [Co-PI].
2000- NIH. SBRI "Effect of a PARS inhibitor in myocardial ischemia reperfusion injury in a porcine model in vivo" [Subcontract PI]
REPORT OF TEACHING
Local Contributions
Undergraduate Medical Education
Northeastern Ohio Universities College of Medicine
1983-87 Core Surgical Clerkship, Akron City Hospital
William V. Sharp, MD, Course Director
Conducted daily morning and afternoon rounds with medical students, participated
in weekly educational conferences and morbidity and mortality conferences, intraoperative
teaching. 1 or 2 students per month, 9 months per year, 12 hours per week.
University of Iowa College of Medicine
1987-90 Surgical (cardiothoracic) clerkship for junior
and senior medical students, Douglas M. Behrendt, MD, Director
Conducted daily rounds with medical students, intraoperative teaching.
1 or 2 students per month, 9 months per year, 6 hours per week
Harvard Medical School
1990- Preceptor, Junior medical student core clerkship
in surgery (SU600M.5), Michael Cahalane, MD, Course Director,
3 students per year, 6 hours per week. Daily teaching rounds 1to 3 hours per
week, intraoperative instruction in surgery, 6 hours per week
1990- Preceptor, Senior medical student surgical
clerkship in cardiothoracic surgery (SU504M.1), Ronald M. Weintraub, MD, Course
Director (1990- 99) Daily rounds with senior medical students and other medical
students and residents, intraoperative instruction during surgery, 4 student
per year, 3 hours per week
1992; Preceptor for Juliann Reiland-Smith, Senior medical student surgical clerkship
in cardiothoracic surgery, 12 hours per week for 4 weeks
1992 Patient-Doctor Year II (Introduction to clinical medicine, IN709M.Jb). Booker Bush, MD, Program Director, Instruction in cardiovascular and thoracic physical examination, 2 students per term, 3 hours per week, shared responsibility with 2 colleagues
1993-96 Treatment of Cardiac Failure: Basic science and clinical aspects (ME547.1). Judith Gwathmey, DVM, PhD,Course Director, 1 hour lecture and 2 hours discussion per session 1-2 times per year, 15 senior students per course
1999- Director, Senior medical student surgical clerkship in cardiothoracic surgery (SU504M.1) Daily rounds with senior medical students and other medical students and residents, intraoperative instruction during surgery, 4 student per year, 3 hours per week
Harvard Medical School-Massachusetts Institute of Technology-HST Program
1994-96 Member and clinical advisor, Ph.D. Advisory Committee for Naomi Chesler, Thesis entitled: "Ventricular assist device design and analysis: A computational approach", Roger Kamm, PhD, Advisor, Biomedical Engineering, 8 hours per 3 month period
Graduate Medical Education
1983-87 Akron City Hospital Surgery Residency Program
Northeastern Ohio Universities College of Medicine,
C. William Loughry, MD, Director (1983-86) William Sharp, MD, Director (1986-87).
Conducted daily morning and afternoon rounds with 1-3 surgery residents (PGY
1-4), organized and participated in weekly educational conferences. Teaching
assistant in surgery. 12 months per year, 16 hours per week
1987-90 University of Iowa College of Medicine Surgical
Residency, Nelson J. Gurll, MD, Director, Daily rounds and instruction in cardiothoracic
surgery, 2 junior residents (PGY 1-3) per month, 12 months per year,
8 hours per week
Beth Israel Hospital (1990-96); Beth Israel Deaconess Medical Center (1996-
)
1990- General Surgery Resident teaching, John J.
Skillman, MD, Director
(1990-92), Robert Johnson, MD (1993-96), Michael Stone, MD (1996- ) 1 or 2 junior
residents per month, one senior resident per month). Daily teaching rounds,
Instruction and assisting at surgery (cardiac and thoracic). 12 months per year,
8 hours per week
1990- Cardiac Surgery Fellowship (non-RRC approved), Ronald M. Weintraub, MD, Director (1990-96), Robert G. Johnson, MD (1996-99) 2 post graduate fellows (post surgery or post thoracic surgery residency) per year, Daily teaching rounds, instruction and assisting at surgery (cardiac), 12 months per year, 12 hours per week
2000- Cardiothoracic Surgery Residency, Sidney Levitsky,
MD (1996-97),
Robert G. Johnson, MD (1997-99), Frank Sellke MD (1999- ) Residency Director,
Instruction and assisting at surgery (cardiac and thoracic), Participation in
weekly morbidity and mortality conference and teaching conferences, 1 junior
(PGY-6) and 1 senior (PGY-7) resident per year, 12 months per year, 6 hours
per week
1999- Director, Cardiothoracic Surgery Residency Training
Program,
Organization and administration of conferences and training program,
1 junior (PGY-6) and 1 senior (PGY-7) resident per year, 12 months per
year, 12 hours per week
1999- Director, Cardiac Surgery Fellowship (non-RRC approved), 2 post graduate fellows (post surgery or post thoracic surgery residency) per year, Daily teaching rounds, instruction and assisting at surgery (cardiac), 12 months per year, 4 hours per week
Advisory and Supervisory Responsibilities in Laboratory
Research Trainee (Pre-doctoral research fellows)
Present position below name.
1996-97 Christina Vassileva Student at Northeastern
University. Altered (Johns Hopkins Medical blood flow and blood flow regulation
by School, 1998- ) ischemic preconditioning. 6 months,
8 hours per week of supervision and counseling)
1997, 98 Jennifer Lee Student at Smith College. Volunteer research assistant during summer vacation. Microvascular regulation after cardiac surgery in patients. 4 hours per week of supervison and counseling)
1999-01 Eugenio Goncalves PhD graduate student, Thesis:
Tyrosyl
de Araujo phosphorylation and vascular permeability in
cardiac surgery
Research Trainees (Post-doctoral research fellows)
Close supervision of research and directing research program (12 hours per week), present position below name.
1990-92 Tajammul Shafique, MD. Effects of cardiopulmonary
bypass and (surgery resident, Beth Israel cardioplegia on vascular reactivity
Hosp. & Univ. of Missouri
1992-96; private practice
in surgery)
1990-93 Hai Bin Dai, MD. Coronary arteriolar and venular vasomotor (research assoc., BIDMC) regulation. Effects of inhalation and intravenous anesthetics on coronary and cerebral microvascular regulation.
1991-92 Peter F. Banitt, MD Relaxation responses
of coronary arterioles (cardiology fellow, Brigham and venules after blood cardioplegia.
& Women's Hosp. 1992-96;
cardiologist, private practice)
1992-94 Robert N. Piana, MD Effects of ischemia-reperfusion and the (interventional
cardiologist, angiotensin converting enzyme inhibition on Brigham & Women's
Hosp; coronary endothelial function and myocardial Assist. Prof of Med., HMS)
recovery. Coronary microvascular endothelial function and radiographic contrast
media.
1993-95 Menachem Friedman, MD Effects of cardiopulmonary bypass on (cardiac surgeon, Rabin pulmonary vascular reactivity. Effect of Medical Center, Israel bFGF on collateral-dependent perfusion.
1993-96 Steven Y. Wang, MD, PhD Effects of cardiopulmonary bypass on (Assist Prof of Anesthesia, coronary, pulmonary and cerebrovascular Brigham & Women's Hosp, vasomotor regulation. Effect of bFGF and Harvard Med. School) VEGF on collateral-dependent perfusion. Altered blood flow regulation during endotoxemia and sepsis. Heterogeneous coronary vasodilation of organic nitrates.
1993-96 Jianyi Li, MB, MS In vitro microvascular pharmacology and (research assoc., BIDMC) effects of growth factors on vascular regulation.
1993-96 Kyung W. Park, MD Coronary and cerebral microvascular (Anesthesiologist, BIDMC vasomotor regulation. Effects of inhalation Asst. Prof. Anesth. HMS) and intravenous anesthetics on coronary and microvascular regulation. Flow-mediated regulation of vascular tone.
1994-95 Mukesh D. Jain, MD Intrinsic tone of coronary
resistance arteries.
(Assist Prof of Med, Brigham
&Women's Hosp, HMS)
1994-95 Kenneth Pfahler, MD Cocaine and the human
coronary
(cardiology fellow, Emory; microcirculation.
private practice in cardiology)
1995-97 Alon Stamler, MD Effects of cardiopulmonary bypass on (cardiac surgeon, Rabin coronary and cerebrovascular vasomotor Medical Center, Israel) regulation and vascular permeability. Effect of bFGF and VEGF on collateral-dependent perfusion.
1995-98 Motohisa Tofukuji, MD, PhD Effects of cardiopulmonary
bypass and (Assist. Prof. Surg, Tohoku blood, magnesium and potassium Univ.,
Sendai Japan) cardioplegia on coronary and cerebrovascular vasomotor regulation
and intracellular calcium handling. Effect of bFGF and VEGF on collateral-dependent
perfusion, myocardial function, and gene expression. Altered blood flow and
blood flow regulation by ischemic preconditioning. Clotrimazole and coronary
microvascular regulation.
Finalist: Vivien Thomas Research Award; American Heart Association, 1998
1996-98 Chantal Dessy, PhD In vitro microvascular pharmacology and (researcher, Catholic Univ. alterations in intracellular calcium of Louvain, Brussels) mobilization during magnesium and potassium cardioplegia.
1996-98 Mukesh Hariawala, MD Therapeutic angiogenesis, Effects of (research and clinical fellow cardiopulmonary bypass and blood, in cardiac surgery, London) magnesium and potassium cardioplegia on coronary and cerebrovascular vasomotor regulation.
1997-99 Caroline Metais, MD Altered gene and protein
expression of (Staff Anesthesiologist, Paris) VEGF, bFGF and nitric oxide isoforms
after CPB and crystalloid cardioplegia and after ischemic preconditioning. Altered
reactivity of human coronary microvessesl by hypercholesterolemia.
Finalist: Vivien Thomas Research Award; American Heart Association, 1998
1998-00 Naruto Matsuda, MD, PhD Changes in microvascular
intracellular (Assist Prof of Surgery, calcium handling, myosin light chain
Tottori Univ School of Med.) phosphorylation, protein kinase C
translocation after extracorporeal circulation and blood and Mg-based cardioplegia.
1998-00 Kaori Sato, MD Therapeutic angiogenesis using protein (Research Assoc.
BIDMC). growth factors and adenoviral vectors,
vascular permeability effects of
extracorporeal circulation
1999-00 Jian-Ping Zhang, MD Detrimental effect of
CPB
(Biologist, Eli Lilly)
1999-00 Xunyu Xu, MD Therapeutic angiogenesis,
(Assist Prof of Surg, China) effects of myocardial ischemia on growth factor
expression in patients
1999-00 Alec Li, PhD Regulation of tyrosyl phosphorylation
(Harvard Med School)
1999- Renato Faro, PhD PARS inhibition and CPB
2000- Marc Ruel, MD Clinical and experimental angiogenesis
Continuing Medical Education
Faculty Workshop: Young Surgical Investigators' Conference, American College
of Surgeons, Surgical Research and Education Committee. March 30 - April 1,
1996, Chantilly, VA. Conducted 2 seminars (2-3 hours each) on grantsmanship
and successful grant writing in cardiothoracic surgical research, participated
in overall program for duration of course.
Faculty Workshop: Young Surgical Investigators' Conference, American College of Surgeons, Surgical Research and Education Committee. March 12 - 13, 2000, Chantilly, VA. Conducted seminar (3 hours) on grantsmanship and successful grant writing in cardiothoracic surgical research, participated in overall program for duration of course.
Invited presentations
Local and Regional
1990 Cardiology Grand Rounds, Beth Israel Hospital. "Alterations of endothelium-
dependent coronary microvascular relaxation in atherosclerosis"
1991 Surgical Grand Rounds, Beth Israel Hospital. "Changes in microvascular regulation in atherosclerosis"
1992 Anesthesia and Critical Care Grand Rounds, Beth Israel Hospital. "Thoracic trauma"
1992 Primary Care Grand Rounds, Beth Israel Hospital. "Evaluation of the solitary pulmonary nodule."
1992 Cardiology Grand Rounds, Beth Israel Hospital. "Alterations of coronary microvascular responses during cardiopulmonary bypass and cardiac surgery"
1993 Beth Israel Hospital Emergency Unit Conference. "Thoracic trauma"
1993 Cardiac surgery research conference. Massachusetts General Hospital. "Altered microvascular reactivity during cardiac surgery"
1994 Surgical Basic Science Lecture Series. Beth Israel Hospital. "Cardiac electrophysiology and chronic heart failure"
1994 Vascular Biology Group Meeting. Beth Israel Hospital. "Changes in coronary vascular responses after cardioplegia and cardiac surgery"
1994 Vascular Biology Group Meeting. Beth Israel Hospital. "Microvascular endothelial responses in angiogenesis and ischemia"
1994 Featured Lecture. American Heart Association, Massachusetts affiliate staff workshop. "Basic fibroblast growth factor improves myocardial and vascular function in chronically ischemic hearts" Framingham MA.
1994 Cardiovascular Research Seminar. St. Elizabeth's Hospital "Alterations in Coronary and Pulmonary Microvascular responses during Cardiac Surgery". Brighton MA.
1995 Clinical pathological conference. Beth Israel Hospital. "Surgical treatment of cardiac tumors"
1996 Cardiology Grand Rounds, Beth Israel Hospital, "Changes in regulation of vascular tone during cardiac surgery"
1996 Moderator, Harvard Academic Cardiothoracic Surgical Conference. Beth Israel Hospital
1996 Surgical Basic Science Lecture Series, "Coronary
Artery Disease"
Beth Israel Hospital
1997 Division of cardiothoracic surgery research conference. Beth Israel Deaconess Medical Center, "VEGF in angiogenesis"
1997 Surgical Grand Rounds. West Roxbury Veteran's
Administration
Medical Center "Growth factor-induced angiogenesis for the treatment of
patients with coronary artery disease", West Roxbury MA
1998 Cardiac Surgical Grand Rounds. Brigham and Women's
Hospital. "Angiogenesis
in the heart: Implication for the treatment of patients with inoperable coronary
artery disease ", Boston MA
1999 Pathology Research Seminar, Beth Israel Deaconess
Medical Center
"Coronary microcirculation and angiogenesis", Boston, MA
1999 New England Baptist Hospital, "Therapeutic coronary angiogenesis" Boston, MA
2000 Surgical Grand Rounds, Beth Israel Deaconess Medical Center, "Therapeutic coronary angiogenesis", Boston, MA
2000 Cardiothoracic Surgery Teaching conference, Beth
Israel Deaconess Medical
Center, "Vascular changes after heart surgery", Boston, MA
2000 Surgery Grand Rounds, Mt. Auburn Hospital, "Therapeutic
angiogenesis for the
treatment of inoperable coronary artery disease", Cambridge MA
2000 Invited Lecturer: Baystate Medical Center, "Therapeutic
angiogenesis for the
treatment of inoperable coronary artery disease", Springfield MA
2000 Invited Lecturer: Medical Grand Rounds, "Therapeutic
angiogenesis for the
treatment of inoperable coronary artery disease", Our Lady of Fatima Hospital,
Providence RI
2001 Speaker: Scientific Symposium, Basic Research
in the BIDMC Department of
Surgery, Boston MA
National and International Contributions
1993 Moderator, New techniques in myocardial protection, American Heart Association Meeting, Atlanta GA
1994 Invited Lecturer, Anesthesiology research conference, Johns Hopkins Hospital. Baltimore MD
1994 Invited Lecturer, Department de Chirugie Cardio-Vasculaire- Hospital Broussais, Paris, France
1994 Lecturer, Merck Research Conference, Blue Bell PA
1994 Lecturer, Cardiology and Cardiac Surgery Grand Rounds. Philadelphia Heart Institute, Presbyterian Medical Center, Philadelphia PA
1994 Moderator, Coronary Collateral Circulation,
American Heart Association Scientific
Sessions, Dallas TX
1995 Invited Lecturer, New Zealand Regional Scientific Meeting, Cardiac Society of Australia and New Zealand, Dunedin, New Zealand
1995 Moderator, Molecular mechanisms of myocardial
protection. American
Heart Association Scientific Sessions, Anaheim CA
1996 Invited lecturer, 41st Alfred Benzon Symposium, Danish Royal Academy of Arts and Science, Copenhagen, Denmark
1997 Invited Lecturer, American Heart Association
Cardiovascular Seminar, Orlando FL
1997 Moderator, Myocardial Protection, American Heart Association Scientific
Sessions, Orlando FL
1997 Invited Lecturer, 1st International Congress on Coronary Artery Disease, Prague, Czech Republic
1998 Instructor in the proper surgical implantation of heparin alginate devices, Montefiore Hospital. Albert Einstein School of Medicine, New York NY
1998 Moderator, Myocardial Protection, American Heart
Association Scientific
Sessions, Dallas TX
1998 Invited Lecturer, American Heart Association Cardiovascular Seminar, Dallas TX
1998 Invited Lecturer. Cardiothoracic Surgery Grand
Rounds, University of Iowa
College of Medicine, Angiogenesis in the heart, Iowa City IA
1999 Invited Lecturer: Cardiovascular Grand Rounds.
Hospital das Clinicas da
Faculdade de medicina da Universidade de Sao Paulo, Brazil.
1999 Invited Lecturer: Department of Pharmacology. Universidade de Sao Paulo, Brazil.
1999 Invited Lecturer: NO in Brazil: Basic and Clinical
Aspects of Nitric Oxide.
Foz do Iguacu, Brazil.
1999 Invited Lecturer: Biological Institute, University of Brazilia, Brazil.
1999 Moderator, University Surgeons Resident's Conference. New Orleans.
1999 Invited Lecturer: Carolina Heart Institute. Charlotte, NC.
1999 Invited Lecturer: University of Iowa College of Medicine
1999 Invited Lecturer: American College of Surgeons
Surgical Biology Club-1
1999 Invited Lecturer: Angiogenesis Foundation Consensus Meeting
2000 Moderator, University Surgeons Resident's Conference. Toronto.
2000 Moderator, Society of University Surgeons, Toronto
2000 Invited Lecturer: Texas A&M University. College
Station, TX.
2000 Invited Lecturer: Bethesda Hospital, Cincinnati, OH
2000 Invited Lecturer: European Society of Surgical Research, Malmo, Sweden
1999 Moderator: European Society of Surgical Research, Malmo, Sweden
2000 Moderator: Basic Science in Myocardial Protection,
American Heart Association
Meeting, New Orleans
2000 Invited Lecturer: Nitric oxide and the human
coronary microcirculation, American
Heart Association Meeting, New Orleans
2001 Moderator: Cardiac Research, Society of Thoracic Surgeons Meeting, New Orleans
2001 Moderator, University Surgeons Resident's Conference. Chicago.
2001 Invited Lecturer: Japanese Surgical Society, Sendai, Japan
2001 Invited Lecturer: Wabash College, Crawfordsville
IN
Clinical Activities:
My clinical practice in surgery has concentrated on cardiothoracic surgery.
When I arrived in 1990, the distribution of cases was approximately 70% cardiac
and 30% general thoracic surgery and thoracic trauma. With time, the distribution
gradually changed such that cardiac surgery increased and general thoracic surgery
decreased in relative terms. In 1996, by mutual agreement with my clinical colleagues,
I began concentrating totally on cardiac surgery. The case mix is listed below.
1990-present Cardiac surgery- myocardial revascularization, valve repair and replacement, cardiac tumors, surgical electrophysiology, aortic and great vessel surgery, alternative methods of myocardial revascularization (therapeutic angiogenesis using protein growth factors)
1990-96 General thoracic surgery- Pulmonary surgery
for malignancy, benign
tumors and congenital malformations, mediastinal pathology, esophageal surgery,
chest wall tumors and infection in the thorax
Time commitments:
Clinical surgery 50%
Teaching and administration 20%
Research 30%
Patient load:
Presently, I perform 180 to 250 cardiothoracic surgical operations
(with cardiopulmonary bypass) per year and approximately 10 cardiac surgical
cases not involving cardiopulmonary bypass.
Clinical program development:
I am the principal surgical investigator in development of therapeutic angiogenesis
for treatment of patients with inoperable coronary artery disease [NIH P50 HL
56993]. I developed the surgical technique to implant heparin alginate slow
release devices containing basic fibroblast growth factor [Sellke FW, et al.
Ann Thorac Surg 65: 1540-1544, 1998; Laham RJ, Sellke FW, et al. Circulation
1999; 100: 1865-1871]
As a member of the Cardiology/Cardiac Surgery Outreach program, co-chairman of the Cardiology/Cardiac Surgery volume initiative, and Interim Chief of Cardiothoracic Surgery, I have been active in increasing the volume of patients admitted to BIDMC from the community, and in improving ties with referring physicians. I am actively involved in improving quality of care of cardiac surgical patients on both East and West campus of BIDMC, and to rapidly consolidate the care of both cardiac surgical and cardiology patients within one facility, and to develop surgical programs and increase volume to the medical center.
As Interim chief of Cardiothoracic Surgery at Beth
Israel Deaconess Medical
Center, and interim chief of Cardiac Surgery at Landmark Medical Center, I have
been closely involved in negotiating and establishing a center of cardiothoracic
surgery and interventional cardiology at Landmark Medical Center in Woonsocket
RI. It is anticipated that we will begin performing open heart surgery at Landmark
in 2001.
PART III
BIBLIOGRAPHY:
Original peer reviewed articles:
1. Lingeman J, Donohue J, Madura J, Sellke FW. Angiomyolipoma: Emerging concepts
in management. Urology 1982; 20: 566-570.
2. Sellke FW. Williams G, Donovan D, Clarke R. Management of intra-abdominal aneurysms associated with periarteritis nodosum. J Vasc Surg 1986; 4: 294-298.
3. Sellke FW Debski R, Ely D, Sadri F, Inman S. Regional mapping, depletion and functional correlation of myocardial catecholamines in an isolated rat heart model. Curr Surg 1986; 43: 476-479.
4. Sellke FW, Williams G. Distal duodenal carcinoma and intussusception. South Med J 1987; 80: 644-648.
5. Sellke FW, Ely D, Sadri F, Debski R. Comparative functional preservation of cold perfusion and non-perfusion in Langendorff isolated rat hearts. Curr Surg 1987; 44: 300-304.
6. Sellke FW, Kelly T. Thoracic outlet syndrome. Am J Surg 1988; 156: 54-57.
7. Sellke FW, Loughry C, Kashkari S. Angiosarcoma of the breast: report of two long-term survivals. Int Surg 1988; 73:193-195.
8. Saaka M, Sellke FW, Kelly T. Primary hyperparathyroidism. Surg Gynecol Obstr 1988; 166: 333-337.
9. Sellke FW, Meng R, Rossi N. Cryopreserved saphenous vein homografts for femoral distal reconstruction. J Cardiovasc Surg 1989; 30: 838-842.
10. Sellke FW, Banitt P, Harrison D. Adrenergic regulation of the coronary microcirculation. Surg Forum 1989; 40: 225-227.
11. Sellke FW, Myers P, Bates J, Harrison D. Influence of vessel size on the sensitivity of coronary microvessels to nitroglycerin. Am J Physiol 1990; 258 (Heart-Circ Physiol 27):H515-H520.
12. Sellke FW, Armstrong ML, Harrison D. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 1990; 81: 1586-1593.
13. Sellke FW, Quillen JE, Brooks LA, Harrison DG. Endothelial modulation of the coronary vasculature in vessels perfused via mature collaterals. Circulation1990; 81:1938-1947.
14. Sellke FW, Lemmer J, Vandenberg B, Ehrenhaft J. Cardiac myxomas: long term results following surgical treatment. Ann Thorac Surg 1990;50: 557-561.
15. Quillen JE, Sellke FW, Brooks LA, Harrison DG. Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels while not affecting large coronary arteries. Circulation 1990; 82: 586-594.
16. Harrison DG, Sellke FW, Quillen JE. Neurohumoral regulation of coronary collateral vasomotor tone. Basic Res Cardiol. 1990; 85 (Suppl): 121-129.
17. Sellke FW, Lazsewski M, Johnson R, Smith R, Rossi NP. Hemangiopericytoma of the sternum. Arch of Path Lab Med 1991; 115: 242-244.
18. Quillen JE, Sellke FW, Harrison DG. Long term hypercholesterolemia alters the reactivity of primate coronary microvessels to platelet products. Arteriosclerosis and Thrombosis 1991; 11: 639-644.
19. Sellke FW, Tomanek R, Harrison DG. L-cysteine selectively enhances nitroglycerin induced relaxation in small coronary microvessels, J Pharm Exper Ther 1991; 258: 365-369.
20. Sellke FW, Stanford W, Rossi NP. Failure of cryopreserved saphenous vein allografts following coronary artery bypass. J Cardiovasc Surgery 1991; 32: 820-823.
21. Quillen JE, Sellke FW, Banitt P, Harrison DG. Effect of norepinephrine on the coronary microcirculation. J. Vasc Research 1992; 1: 2-7.
22. Sellke FW, Quillen JE. Altered effects of vasopressin on the coronary circulation following ischemia. J Thorac Cardiovasc Surg 1992; 104: 357-363.
23. Harrison DG, Kurz MA, Quillen JE, Sellke FW, Mugge A. Normal and pathophysiologic considerations of endothelial regulation of vascular tone: relevance of nitrate therapy. Am J Cardiol 1992; 70: 11B-17B.
24. Ely DL, Dunphy G, Dollwet H, Richter H, Sellke FW, Azodi M. 24 Hour isolated rat heart preservation using deferoxamine. Free Radical Biology and Medicine 1992; 12: 479-485.
25. Sellke FW, Kagaya Y, Johnson RG, Shafique T, Schoen FJ, Grossman W, Weintraub RM. Endothelial modulation of the porcine coronary microcirculation perfused via immature collaterals. Am J Physiol. 1992; 262: H1669-H1675.
26. Breall JA, Goldberger A, Warren S, Diver D, Sellke FW. Posterior mediastinal masses: rare causes of cardiac compression. Am Heart J 1992; 124: 523-526.
27. Sellke FW, Shafique T, Schoen FJ, Weintraub RM. Impaired endothelium-dependent coronary microvascular relaxation following cold potassium cardioplegia and reperfusion. J Thoracic Cardiovasc Surgery 1993; 105: 52-58.
28. Banitt PF, Shafique T, Weintraub RM, Johnson RG, Schoen FJ, Sellke FW. Relaxation responses of the coronary microcirculation after cardiopulmonary bypass and ischemic cardioplegia: implications for the treatment of postoperative coronary spasm. J Cardiothoracic and Vascular Anesthesia 1993; 7: 55-60.
29. Reiland-Smith JA, Weintraub RM, Sellke FW, Traumatic aortic valve injury sustained despite the deployment of an automobile air bag. Chest 1993; 103:1603.
30. Shafique T, Sellke FW, Thurer RL, Weintraub RM, Johnson RG, Cardiopulmonary bypass and pulmonary thromboxane generation. Ann Thorac Surg 1993; 55: 724-728.
31. Sellke FW, Shafique T, Johnson RG, Dai Hai-Bin, Banitt PF, Schoen FJ, Weintraub RM. Blood-and albumin-cardioplegia preserve endothelium-dependent microvascular responses during cardiopulmonary bypass and ischemic arrest. Ann Thorac Surg 1993; 55: 977-985.
32. Shafique T, Johnson RG, Dai Hai-Bin, Weintraub RM, Sellke FW. Altered pulmonary microvascular reactivity following total cardiopulmonary bypass. J Thorac Cardiovasc Surgery 1993; 105:479-486.
33. Sellke FW, Dai Hai-Bin. Responses of porcine epicardial venules to neurohumoral substances. Cardiovasc Res 1993; 27: 1326-1332.
34. Sellke FW, Shafique T, Ely DL, Weintraub RM. Coronary endothelial injury following cardiopulmonary bypass and ischemic cardioplegia is mediated by oxygen-derived free radicals. Circulation 1993; 88 (part 2): 395-400.
35. Sellke FW, Friedman M, Dai HB, Shafique T, Schoen FJ, Weintraub RM, Johnson RG. Mechanisms causing coronary microvascular dysfunction following ischemic cardioplegia and reperfusion. Cardiovascular Research 1993; 27:1925-1932.
36. Nunez BD, Miao L, Wang Y, Nunez MM, Sellke FW, Ross JN, Susulic V, Paik GY, Carrozza JP Jr, Morgan JP. Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm. Circulation Research 1994; 74:281-290.
37. Piana RN, Shafique T, Dai H-B, Sellke FW. Epicardial and endocardial coronary microvascular responses. Effects of ischemia reperfusion. J Cardiovasc Pharmacology l994; 23: 539-546.
38. Sellke FW, Wang SY, Vandermeer TJ, Fink MP. Escherichia coli endotoxemia alters coronary and pulmonary arteriolar responses to platelet products. Shock 1994; 1:279-285.
39. Sellke FW, Friedman M, Wang SY, Piana RN, Dai H-B, Johnson RG. Adenosine and AICA-Riboside fail to enhance microvascular endothelial preservation. Ann Thorac Surg 1994; 58: 200-206.
40. Wang SY, VanderMeer TJ, Fink MP, Sellke FW. Uncoupling of coronary microvascular ß2-adrenoceptors by Escherichia coli endotoxemia Surgery 1994; 116: 307-312.
41. Harada K, Grossman W, Friedman M,Edelman ER, Prasad PV, Keighley C, Manning WJ Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest 1994; 94:623-630.
42. Piana RN, Banitt PF, Nunez BD, Dai-H-B, Sellke FW. Coronary microvascular responses following exposure to iodinated contrast media. Investigative Radiology 1994; 29: 877-881.
43. Sellke FW,Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M. Basic FGF enhances endothelium dependent relaxation of the collateral -perfused coronary microcirculation. Am J Physiol l994; 267: Hl303-Hl3ll.
44. Park KW, Dai-H-B, Lowenstein E, Darvish A, Sellke FW. Heterogeneous vasomotor responses of rabbit coronary microvessels to isoflurane. Anesthesiology 1994; 81:1190-1197.
45. Friedman M, Johnson RG, Wang SY, Dai HB, Thurer RL, Weintraub RM, Sellke FW. Pulmonary microvascular responses to protamine and histamine. Effects of cardiopulmonary bypass. J Thoracic Cardiovasc Surg 1994; 108: 1092-1099.
46. Wang SY, Friedman M, Johnson RG, Weintraub RM, Sellke FW. Adrenergic regulation of the coronary microcirculation after extracorporeal circulation and crystalloid cardioplegia. Am J. Physiol (Heart and Circ Physiol) 1994; 267: H2462-H2470.
47. Friedman M, Sellke FW, Wang SY, Weintraub RM, Johnson RG. Parameters of pulmonary injury after total and partial cardiopulmonary bypass. Circulation 1994; 90: II-262-II-268.
48. Wang SY, Nunez BD, Morgan JP, Dai H-B, Ross JN, Sellke FW. Cocaine and the porcine coronary microcirculation: Effects of chronic cocaine exposure and hypercholesterolemia. J Cardiothorac Vasc Anesth1995; 9: 290-296.
49. Friedman M, Wang SY, Sellke, FW, Franklin A, Weintraub RM, Johnson RG. Pulmonary injury after total or partial Cardiopulmonary bypass with thromboxane synthesis inhibition. Ann Thorac Surg 1995; 59: 598-603.
50. Park KW, Dai H-B, Lowenstein E, Darvish A, Sellke,FW. Oxygen-derived free radicals mediate isoflurane-induced vasoconstriction of rabbit coronary resistance arteries. Anesthesia and Analgesia 1995; 80: 1163-1167.
51. Banitt PF, Dai H-B, Wang SY, Friedman M, Sellke FW. Myogenic and agonist-induced esponses of coronary venules after cold, hyperkalemic cardioplegia. Cardiovasc Res 1995; 29: 827-833.
52. Wang SY, Friedman M, Johnson RG, Zeind AJ, Sellke FW. ATP-Sensitive K+ channels mediate post-cardioplegia coronary hyperemia, J. Thorac Cardiovasc Surg 1995; 110:1073-1082.
53. Wang SY, Friedman M, Franklin A, Sellke FW. Myogenic reactivity of coronary resistance arteries after cardiopulmonary bypass and hyperkalemic cardioplegia. Circulation 1995; 92: 1590-1596.
54. Johnson RG. Sirois C, Watkins JF, Thurer RL, Sellke FW, Cohn WE, Kuntz RE, Weintraub RM. CABG after Successful PTCA: A case-control study. Ann Thoracic Surg 1995; 59: 1391-1396.
55. Sellke FW, Wang SY, Friedman M, Dai H-B, Harada K, Lopez JJ, Simons M. B-adrenergic modulation of the collateral-dependent coronary microcirculation. J. Surg Res 1995; 59: 185-190.
56. Park KW, Dai H-B, Lowenstein E, Darvish A, Sellke FW. Isoflurane attenuates cAMP-mediated vasodilation in rat microvessels. Circulation 1995; 92: II 423-II 427.
57. Park KW, Dai H-B, Lowenstein E, Sellke, FW. Propofol-associated dilation of rat distal coronary arteries in mediated by multiple agents, including endothelium-derived nitric oxide. Anesthesia and Analgesia 1995; 81: 1191-1196.
58. Friedman M, Wang SY, Stahl GL, Johnson RG, Sellke FW. Altered ß-adrenergic and cholinergic pulmonary vascular responses after total cardiopulmonary bypass. J Applied Physiol 1995; 79(6): 1998-2006.
59. Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladstone SR, Friedman Sellke FW., Simons M. Magnetic Resonance Mapping Identifies Benefits Related to VEGF-Stimulated Coronary Collateral Angiogenesis. Nature Medicine 1995; 1:1085-1089.
60. Park KW, Dai H-B, Lowenstein E, Sellke FW, Vasomotor responses of rat coronary arteries to isoflurane and halothane depend on pre-exposure tone and vessel size. Anesthesiology 1995; 83: 1323-1330.
61. Friedman M, Wang SY, Sellke FW, Cohn WE, Weintraub RM, Johnson RG. Neutrophil adhesion blockade with NPC 15669 decreases pulmonary injury after total cardiopulmonary bypass. J Thorac Cardiovasc. Surg 1996; 111: 460-8.
62. Harada K, Friedman M, Lopez JJ, Wang SY, Prasad PV, Pearlman JD, Edelman ER, Sellke FW, Simons M. Vascular endothelial growth factor mediated angiogenesis in chronic myocardial ischemia. Am J Physiol (Heart Circulatory Physiol) 1996; 270:H1791-H1802.
63. Piana RN, Wang SY, Friedman M, Sellke FW. Angiotensin Converting Enzyme Inhibition Preserves Endothelium-dependent Microvascular Responses during short-term ischemia-reperfusion. Circulation 1996; 93:544-551.
64. Sellke FW, Wang SY, Stamler A, Johnson RG, Cohn WE, Weintraub RM. Changes in autonomic response of the cerebral circulation after normothermic extracorporeal circulation. J Thorac Cardiovasc Surg 1996; 111: 450-461.
65. Wang SY, Feelisch M, Harrison DG, Sellke FW, Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185. J. Cardiovasc Pharmacol 1996; 27: 587-593.
66. Park KW, Dai H-B, Lowenstein E, Sellke FW. Steady state myogenic response of rat coronary microvessels is preserved by isoflurane, but not by halothane. Anesthesia and Analgesia 1996; 82: 969-974.
67. Sellke FW, Wang SY, Stamler A, Lopez JJ, Li J, Li JY, Simons M. Enhanced microvascular relaxations to VEGF and bFGF in chronically-ischemic porcine myocardium. Am J Physiol 1996; 271: H713-H720.
68. Dauerman HL, Cutlip DE, Sellke FW. Intracoronary thrombolysis in the treatment of graft closure immediately after CABG. Ann Thorac Surg 1996; 62: 280-283.
69. Sellke FW, Li JY, Stamler A, Lopez JJ, Thomas KA, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996; 120: 182-188.
70. Stamler A, Wang SY, Li JY, Thurer RL, Schoen FJ, Sellke FW. Moderate hypothermia reduces CPB-induced impairment of cerebrovascular responses to platelet products. Ann Thorac Surg 1996; 62: 191-198.
71. Lopez JJ, Edelman ER, Stamler A, Morgan JP, Sellke FW, Simons M. Local perivascular administration of basic fibroblast growth factor: drug delivery and toxacologic evaluation. Drug Metabolism and Disposition 1996; 24: 922-924.
72. Jain M, Dai H-B, Carrozza J, Sellke FW, Morgan KG. Intrinsic tone as potential vascular reserve in conductance and resistance vessels. Circulation 1996; 94: 1083-1088.
73. Park KW, Dai H-B, Lowenstein E, Sellke FW. Protein kinase C-induced contraction is inhibited by halothane, but enhanced by isoflurane. Anesthesia and Analgesia 1996; 83: 286-290.
74. Sellke FW, Boyle EM, Verrier ED. Endothelial cell injury in cardiovascular surgery: The pathophysiology of vasomotor dysfunction. Ann Thoracic Surg 1996; 62: 1222-1228.
75. Park KW, Lowenstein E, Sellke FW. (letter) Reply to: Vasomotor effects of isoflurane in the coronary circulation (Crystal GJ). Anesthesiology 1996; 84: 1517-1518.
76. Park KW, Lowenstein E, Dai H-B, Lopez JJ, Stamler A, Simons M, Sellke FW. Direct vasomotor effects of isoflurane in subepicardial resistance vessels from collateral-dependent and normal circulation of pigs. Anesthesiology 1996; 85: 584-591.
77. Stamler A, Wang SY, Aguirre DE, Sellke FW, Johnson RG. Effects of Pentastarch-deferoxamine conjugate on lung injury after cardiopulmonary bypass. Circulation 1996; 94: II-358-II-363.
78. Wang SY, Stamler A, Tofukuji M, Deuson TE, Sellke FW. Effects of blood and crystalloid cardioplegia on adrenergic and myogenic vascular mechanisms. Ann Thorac Surg 1997; 63: 41-49.
79. Park KW, Dai H-B, Lowenstein E, Darvish A, Sellke,FW. Isoflurane and halothane attenuate endothelium-dependent vasodilatation in rat coronary microvessels. Anesthesia and Analgesia 1997; 84: 278-284.
80. Park KW, Dai H-B, Lowenstein E, Sellke FW. Isoflurane- and Halothane-mediated dilation of distal bronchi in the rat depends on the epithelium. Anesthesiology 1997; 86: 1078-1087.
81. Tofukuji M, Stamler A, Li JY, Franklin A, Wang SY, Hariawala MD, Sellke FW. Effects of magnesium cardioplegia on regulation of the porcine coronary circulation. J Surg Res 1997; 69: 233-239.
82. Wang SY, Cameron EM, Fink MP, Sellke FW. Chronic septicemia alters alpha-adrenergic mechanisms in the coronary circulation. J Surg Res 1997; 69: 61-66.
83. Wang SY, Stamler A, Li JY, Johnson RG, Sellke FW. Decreased myogenic reactivity in skeletal muscle arterioles after hypothermic cardiopulmonary bypass. J Surg Res 1997; 69: 40-44.
84. Hariawala MD, Deshmukh VV, Sellke FW. Insulin resistance: A common factor in the triad of dyslipidemia, hypertension, and coronary artery disease. Am J Med Sci 1997; 313: 104-106.
85. Stamler A, Wang SY, Aguirre DE, Johnson RG, Sellke FW. Cardiopulmonary bypass alters vasomotor regulation of the skeletal muscle microcirculation. Ann Thorac Surg 1997; 64: 460-465.
86. Johnson RG, Sirois C, Thurer RL, Sellke FW, Cohn WE, Kuntz RE, Weintraub RM. Predictors of CABG within one year of successful PTCA: A retrospective, case-control study. Ann Thorac Surg 1997; 64: 3-8.
87. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Pottumarthi P, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. bFGF in a model of chronic myocardial ischemia: Comparison of angiographic, echocardiographic and coronary flow parameters. J Pharm Exper Ther1997; 282: 385-390.
88. Hariawala MD, Sellke FW. Angiogenesis and the heart: Therapeutic implications. Journal of the Royal Society of Medicine 1997; 90: 307-311.
89. Sellke FW, Tofukuji M, Stamler A, Li JY, Wang SY. ß-adrenergic regulation of the cerebral microcirculation after hypothermic cardiopulmonary bypass. Circulation 1997; 96: II-304-II310.
90. Lopez JJ, Laham RJ, Carrozza JP, Tofukuji M, Sellke FW, Bunting S, Simons M. Hemodynamic effects of intracoronary VEGF delivery-Evidence of tachyphylaxis and NO dependence of response. Am J Physiol (Heart and Circulatory Physiology) 1997; 273: H1317-H1323.
91. Park KW, Dai H-B, Ojamaa K, Lowenstein E, Klein I, Sellke FW. Direct vasomotor effect of thyroid hormones on rat skeletal muscle resistance arteries. Anesthesia and Analgesia 1997; 85: 734-738.
92. Tofukuji M, Stamler A, Li JY, Hariawala MD, Franklin A, Sellke FW. Comparative effects of continuous warm blood and intermittent cold blood cardioplegia on coronary reactivity. Ann Thorac Surg 1997; 64: 1360-1367.
93. Tofukuji M, Dessy C, Hariawala MD, Morgan KG, Sellke FW. Magnesium cardioplegia preserves ß-adrenergic regulation and limits calcium influx in the coronary microcirculation. American College of Surgeons Surgical Forum 1997; 48: 331-333.
94. Cameron EW, Wang SY, Fink MP. Sellke FW. Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis. Shock 1998; 9: 184-192.
95. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, Disalvo J, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Angiogenic potential of perivascular delivered aFGF in a porcine model of chronic myocardial ischemia. Am J Physiol 1998; 274: H930-H936.
96. Park KW, Dai H-B, Lowenstein E, Sellke FW. Epithelial dependence of the bronchodilatory effect of sevoflurane and desflurane in rat distal bronchi. Anesthesia and Analgesia.1998; 86: 646-651.
97. Park KW, Dai H-B, Lowenstein E, Stamler A , Sellke FW. Effect of isoflurane on the ß-adrenergic and endothelium-dependent relaxation of pig cerebral microvessels after cardiopulmonary bypass. J Stroke Cerebrovasc Dis 1998; 7: 168-178.
98. Sellke FW, Tofukuji M, Laham RJ, Li JY, Hariawala MD, Bunting S, Simons M. Comparison of VEGF delivery techniques on collateral-dependent microvascular reactivity. Microvasc Res 1998; 55: 175-178.
99. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis in patients using basic-fibroblast growth factor: Technique and early results. Ann Thorac Surg 1998; 65: 1540-1544.
100. Varma N, Sellke FW, Epstein LM. Chronic atrial lead explantation using a staged percutaneous laser and open surgical approach. Pacing and clinical electrophysiology 1998; 21: 1483-1485.
101. Park KW, Dai H-B, Lowenstein E, Sellke FW. Flow-induced dilation of rat coronary microvessels is attenuated by isoflurane, but enhanced by halothane. Anesthesiology 1998; 89: 132-142.
102. Tofukuji M, Metais C, Wang SY, Alper SL, Sellke FW. Clotrimazole is a potent vasodilator of the rat coronary microcirculation. J Surg Res 1998; 77: 6-10.
103. Metais C, Li JY, Li J, Simons M, Sellke FW. Effect of coronary artery disease on expression and microvascular response to VEGF. Am J Physiol (Heart and Circulatory Physiol) 1998; 275: H1411-H1418.
104. Tofukuji M, Metais C, Li JY, Hariawala MD, Franklin A, Vassileva C, Li J, Simons M, Sellke FW. Effects of ischemic preconditioning on myocardial perfusion, function and microvascular regulation. Circulation 1998; 98: II-197-205.
105. Metais C, Li JY, Haering JM, Cohn WE, Simons M, Sellke FW. Altered microvascular regulation by acute myocardial ischemia. American College of Surgeons Surgical Forum XLIX: 258-260, 1998.
106. Tofukuji M, Metais C, Li J, Franklin A, Simons M, Sellke FW. Myocardial VEGF expression after cardiopulmonary bypass and cardioplegia. Circulation 1998; 98: II-242-246.
107. Lopez JJ, Laham RL, Stamler A, Pearlman JD, Bunting S, Kaplan A, Carrozza JP, Sellke FW, Simons M. VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc Res 1998; 40: 272-281.
108. Tofukuji M, Stahl GL, Agah A, Metais C, Simons M, Sellke FW. Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. J Thorac Cardiovasc Surg 1998; 116: 1060-1068.
109. Laham RJ, Simons M, Tofukuji M, Hung D, Sellke FW. Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent relaxation. J Thorac Cardiovasc Surg 1998; 116: 1022-1028.
110. Sellke FW, Richter HW, Dunphy G, Azodi M, Ely DL. Twenty-four hour heart preservation using continuous cold perfusion and copper (II) complexes. J Surg Res 1998; 80: 171-176.
111. Tofukuji M, Metais C, Collard CD, Morse DS, Stahl GL, Nelson DP, Li J, Simons M, Sellke FW. Effect of sialyl Lewisx-oligosaccharide on myocardial and cerebral injury in the pig. Ann Thorac Surg 1999; 67: 112-119.
112. Sellke FW, Park KY, Lowenstein E. (letter): Vascular effects of isoflurane: no inconsistency between data. Anesthesiology 1999; 90: 919-920.
113. Bianchi C, Sellke FW, Del Vecchio R, Tonks NK, Neel BG. Receptor-type protein-tyrosine phosphatase µ (RPTPµ) is expressed in specific vascular endothelial beds in vivo. Experimental Cell Research 1999; 248: 329-338.
114. Matsuda N, Tofukuji M, Morgan KG, Sellke FW. Coronary microvascular protection with magnesium: Effects on intracellular calcium and vascular function. Am J Physiol 1999; 276: H1124-H1130.
115. Park KW, Dai H-B, Lowenstein E, Sellke FW. Effect of sevoflurane and desflurane on the myogenic contraction and flow-induced dilation in rat coronary arterioles. Anesthesiology 1999; 90: 1422-1427.
116. Dunphy G, Richter HW, Azodi M, Weigand J, Sadri F, Sellke F, Ely D. The effects of mannitol, albumin and cardioplegia enhancers on twenty-four hour rat heart preservation. Am J Physiol 1999; 276: H1591-H1598.
117. Laham RJ, Rezaee M, Post M, Sellke FW, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: Myocardial and tissue distribution. Drug Metabolism and Disposition 1999; 27: 821-826.
118. Park KW, Tofukuji M, Metais C, Comunale M, Dai HB, Simons M, Stahl GL, Agah A, Sellke FW. Attenuation of endothelium-dependent dilation of pig pulmonary arterioles following cardiopulmonary bypass is mediated by complement C5a. Anesthesia and Analgesia 1999; 89: 42-48.
119. Matsuda N, Tofukuji M, Morgan KG, Sellke FW. Influence of oxygenation on endothelial modulation of coronary vasomotor function during hyperkalemic cardioplegia. Surgery 1999; 126: 264-271.
120. Tofukuji M, Matsuda N, Dessy C, Morgan KG, Sellke FW. Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions. J Thorac Cardiovasc Surg 1999; 118: 163-172.
121. Cohn WE, Sellke FW, Sirois C, Johnson RG. Surgical intensive care unit recidivism after cardiac operation. Chest 1999; 116: 688-692.
122. Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown D, Gold J, Simons M. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: Results of a phase 1 randomized, double-blind, placebo-controlled trial. Circulation 1999; 100: 1865-1871.
123. Matsuda N, Morgan KG, Sellke FW. Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: Role of KATP channels. J Thorac Cardiovasc Surgery 1999; 118: 438-445.
124. Metais C, Li JY, Li J, Simons M, Sellke FW. Serotonin-induced coronary contraction increases after blood cardioplegia-reperfusion: Role of COX-2 expression. Circulation 1999; 100: II-328-II334.
125. Matsuda N, Morgan KG, Sellke FW. Preconditioning inhibits Ca2+ accumulation in coronary smooth muscle and prevents vasospasm during and after hyperkalemic cardioplegia through a KATP channel mechanism. American College of Surgeons Surgical Forum 1999; vol. L: 91-92.
126. Tofukuji M, Stahl GL, Metais C, Tomita M, Agah A, Bianchi C, Fink MP, Sellke FW. Mesenteric dysfunction after cardiopulmonary bypass: Role of complement C5a. Ann Thorac Surg 2000; 69: 799-807.
127. Li J, Post M, Volk R, Gao Y, Li Min, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Li JY, Sellke F, Carmeliet P, Simons M. Novel peptide regulator of angiogenesis. Nature Medicine 2000; 6: 49-55.
128. Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharm Exp Ther 2000; 292: 795-802.
129. Park KW, Sato K, Dai HB, Comunale ME, Sellke FW. Epithelium-dependent bronchodilation is preserved in pig bronchi following normothermic CPB. Anesthesia and Analgesia 2000; 90: 778-783.
130. Park KW, Hai H-B, Comunale M, Gopal A, Sellke FW. Dilation by isoflurane of preconstricted very small arterioles from human right atrium is mediated by KATP channel-opening. Anesthesia & Analgesia. 2000; 91: 76-81.
131. Matsuda N, Morgan KG, Sellke FW. Effects of pinacidil on coronary Ca 2+ - myosin phosphorylation pathway in a cold potassium cardioplegia model. Am J Physiol 2000; 279: H882-H888.
132. Dessy C, Matsuda N, Hulvershorn J, Sougnez CL, Sellke FW, Morgan KG. Evidence for involvement of the PKC alpha isoform in myogenic contraction of the coronary microcirculation. Am J Physiology 2000; 279: H916-H923.
133. Matsuda N, Sellke FW. Regulation of coronary myoplasmic Ca 2+ - myosin phosphorylation and vasomotor tone: Hyperpolarizing vs depolarizing cardioplegia. Surgery 2000; 128: 185-191.
134. Sato K, Li JY, Metais C, Bianchi C, Sellke FW. Increased pulmonary vascular contraction to serotonin after cardiopulmonary bypass: Role of inducible cyclooxygenase. J Surg Res 2000; 90: 138-143.
135. Bianchi C, Sellke FW. COS cells expression cloning of tyrosine-phosphorylated proteins by immunocytochemistry. J Histochem Cytochem 2000; 48: 1097-1101.
136. Sato K, Wu T, Laham RJ, Pearlman JD, Sellke FW, Simons M, Post MJ. Efficacy of intracoronary versus venous FGF-2 in a pig model of chronic myocardial ischemia. Ann Thoracic Surg 2000; 70: 2113-2118.
137. Simons M, Bonow RO, Chronos N, Cohen DJ, Giordano F, Hammond HK, Laham RJ, Li W, Pike M, Sellke FW, Stegmann T, Udelson JE, Rosengart T. Clinical Trials in coronary angiogenesis-Issues, Problems, Consensus- Expert panel summary. Circulation 2000; 102(11): E73-E86.
138. Schermerhorn ML, Tofukuji M, Khoury PR, Phillips L, Hickey PR, Sellke FW, Mayer JE, Nelson DP. Sialyl Lewis X oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic cardiopulmonary bypass in lambs. J Thorac Cardiovasc Surgery 2000; 120: 230-237.
139. Araujo E, Bianchi C, Sato K, Sellke FW. Changes in activities of 42/44 MAP kinases by cardiopulmonary bypass. American College of Surgeons Surgical Forum 2000; LI: 142-144.
140. Metais C, Bianchi C, Li JY, Li, J, Simons M, Sellke FW. Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition. Basic Research in Cardiology 2001; 96: 59-67
141. Sato K, Wu T, Laham RJ, Johnson RB, Douglas PS, Li JY, Sellke FW, Bunting S, Simons M, Post MJ. Efficacy of intracoronary versus intravenous VEGF165 in a pig model of chronic myocardial ischemia. J Am Coll Cardiol 2001; 37: 616-623.
142. Cohn WE, Weintraub RM, Sellke FW. Innovative minimally invasive surgical approaches to coronary revascularization in the high risk patient. Heart Surgery Forum 2000; 3: 185-188.
143. Xu X, Li J, Simons M, Li JY, Laham RJ, Sellke FW. Expression of VEGF and its receptors is increased but microvascular relaxation is impaired in patients after acute myocardial ischemia. Journal of Thorac Cardiovasc Surg 2001; 121: 735-742
144. Araujo EG, Bianchi C, Li XA, Sato K, Sellke FW. Inactivation of the MEK/ERK pathway in the myocardium during cardiopulmonary bypass. J Thorac Cardiovasc Surg 2001; 121: 773-781
145. Park KW, Metais C, Dai, HB, Comunale M, Sellke FW. Microvascular endothelial dysfunction in a rat model of subarachnoid hemorrhage. Anesthesia & Analgesia. 2001; 92: 990-996
146. Araujo EG, Bianchi C, Faro R, Sato K, Sellke FW. Oscillation in the activities of MEK/ERK 1/2 during cardiopulmonary bypass. Surgery (in press).
147. Araujo E, Bianchi C, Sato K, Sellke FW. Biochemical and structural evidence for pig myocardium adherens junctions disruption by cardiopulmonary bypass. Circulation (in press).
Abstracts (not yet published in manuscript form)
1. Seifert MJ, Friedman M, Sellke FW, Josephson ME. Radiofrequency maze ablation
for atrial fibrillation. [abstract] Circulation l994; 90: I-594.
2. Laham R, Tofukuji M, Sellke FW , Simons M. Vascular endothelial growth factor (VEGF) affects microvessels but not epicardial coronary arteries and veins. [abstract] Circulation 1997; 96: I-551.
3. Laham R, Rezaee M, Li J, Post MJ, Tofukuji M, Sellke FW. Adaptive responses of ischemic microvessels: Increased expression of inducible nitric oxide synthase (iNOS) but not endothelial NOS (eNOS). [abstract] Circulation 1997; 96: I-355.
4. Laham RJ, Ji JY, Sellke FW. Myocardial ischemia induced endothelium-dependent vasodilation unrelated to excess nitric oxide generated by increased expression of inducible nitric oxide synthase. [abstract] Circulation 98: I-666, 1998. Presented at the 71st American Heart Association Scientific Sessions, November 1998, Dallas TX.
5. Laham RJ, Sellke FW, Pearlman RD. Magnetic resonance blood-arrival maps provides accurate assessment of myocardial perfusion and collateralization in therapeutic angiogenesis. [abstract] Circulation 98: I-373, 1998. Presented at the 71st American Heart Association Scientific Sessions, November 1998, Dallas TX.
6. Li J, Hampton TG, Metais C, Ma L, Li JY, Amende I, Sellke FW, Douglas PS, Morgan JP, Simons M. Cardiac specific overexpression of PR-39 induces angiogenesis, myocardial hypertrophy, and increased microvascular reactivity. [abstract] Circulation I-794, 1998. Presented at the 71st American Heart Association Scientific Sessions, November 1998, Dallas TX.
7. Park KW, Dai HB, Gopal A, Sellke FW. Cerebral microvascular endothelial dysfunction in a rat model of subarachnoid hemorrhage. [abstract]. Anesthesia and Analgesia (in press). Accepted at the Annual meeting of the Society for Cardiovascular Anesthesiologists.
8. Sato K, Li JY, Metais C, Bianchi C, Sellke FW. Increased pulmonary vascular contraction to serotonin after cardiopulmonary bypass: Role of inducible cyclooxygenase. Accepted at the 33rd Annual meeting of the Association for Academic Surgery. Philadelphia PA. Nov. 18-20, 1999.
9. Sato K, Post MJ, Johnson RB, Pearlman JD, Laham RJ, Sellke FW. How to evaluate the effect of angiogenic strategies on regional myocardial blood flow. [abstract] Circulation (in press). Accepted at the 72nd American Heart Association Scientific Sessions, November 1999, Atlanta GA.
10. Matsuda N, Morgan KG, Sellke FW. Pinacidil prevents hyperkalemia-induced activation of the coronary Ca2+ -myosin light chain phosphorylation pathway: Role in prevention of coronary vasospasm. [abstract] Circulation (in press). Accepted at the 72nd American Heart Association Scientific Sessions, November 1999, Atlanta GA.
11. Li J, Post M, Gao Y, Metais C, Aird W, Sellke FW, Hampton TG, Careliet PP, Simons M. Proteasome-dependent regulation of angiogenesis- A novel therapeutic approach. [abstract] Circulation (in press). Accepted at the 72nd American Heart Association Scientific Sessions, November 1999, Atlanta GA.
12. Li J, Hampton TG, Li JY, Metais C, Tkachenko E, Sellke FW, Simons M. Cardiac-specific expression of syndecan-4 enhances nitric oxide release in response to bFGF. [abstract] Circulation (in press). Prexented at the 72nd American Heart Association Scientific Sessions, November 1999, Atlanta GA.
13. Park KW, Metais C, Dai H-B, Comunale ME, Gopal A, Sellke FW. Mechanism of cerebral microvascular endothelial dysfunction in a rat model of subarachnoid hemorhage. To be presented at the ISAR meeting, Hawaii. Anesthesia & Analgesia. (in press).
14. Park KW, Dai H-B, Comunale ME, Gopal A, Sellke FW. High dextrose concentration attenuates endothelium-dependent dilation, but not ATP-sensitive K+ channel-mediated dilation of rat coronary arterioles. To be presented at the ISAR meeting, Hawaii. Anesthesia & Analgesia. (in press).
15. Li J, , Metais C, Hampton TG, Li JY, Sellke FW, Simons M. Cardiac-specific overexpression of syndecan-4 induces nitric oxide release in response to bFGF. Presented at the 61st Annual meeting of the Society of University Surgeons. Toronto Canada, February 9-12, 2000.
16. Matsuda N, Morgan KG, Sellke FW. Regulation of coronary myoplasmic Ca2+-myosin phosphorulation and vasomotor tone: Hyperpolarizing vs depolarizing cardioplegia. Presented at the 61st Annual meeting of the Society of University Surgeons. Toronto Canada, February 9-12, 2000.
17. Laham RJ, Renaee M, Garcia L, Post M, Sellke FW, Simons M. Tissue and myocardial distribution of intracoronary , intravenous, and intramyocardial 125 I - labeled basic fibroblast growth factor favor intramyocardial delivery. JACC 35: 10A, 2000. Presented at the 49th meeting of the American College of Cardiology. Anaheim CA.
18. Matsuda N, Morgan KG, Sellke FW. Regulation of coronary myoplasmic Ca 2+-myosin phosphorulation and vasomotor tone: Hyperpolarizing vs depolarizing cardioplegia. Presented at the Annual meeting of the European Society of Surgical Research. Malmo, Sweden June 1-3, 2000.
19. Park KW, Metais C, Dai HB, Comunale ME, Gopal A, Sellke FW. Cerebellar microvascular endothelial dysfunction and its mechanism in a rat model of subarachnoid hemorrhage. Anest Anal 90: SCA 78, 2000. Presented at the Meeting of the Society of Cardiovascular Anesthesiologist, May 2000.
20. Park KW, Metais C, Dai HB, Comunale ME, Sellke FW. Heterogeneous expression of nitric oxide synthase in different regions of the rat brain. Anesth Anal 90: SCA 77, 2000. Presented at the Meeting of the Society of Cardiovascular Anesthesiologist, May 2000.
21. Johnson RG, Thurer RL, Sellke FW, Cohn WE, Sirois CA, Weintraub RM. A comparison of objective versus subjective post-CABG mortality predictions. Chest 118: 86S, 2000. Presented at the Chest 2000 meeting, San Francisco CA, October 22-26, 2000.
22. Li XA, Bianchi C, Sellke FW. Rat aortic smooth muscle cell density affects activation of MAP kinase and AKT by menadione and PDGF. Accepted for presentation at the meeting of the Association for Academic Surgery, Nov 2-4, 2000. Tampa FL.
23. Araujo E, Bianchi C, Sato K, Faro R, Sellke FW. Oscillations in the activities of MEK/ERK1/2 during cardiopulmonary bypass in pigs. Accepted for presentation at the meeting of the Society of University Surgeons, Feb 2001, Chicago IL.
24. Araujo E, Bianchi C, Sato K, Sellke FW. Biochemical and structural evidence for pig myocardium adherens junctions disruption by cardiopulmonary bypass. Circulation, 2000. Presented at the American Heart Association Scientific Sessions, Nov 2000. New Orleans.
25. Laham RJ, Sellke FW, Baim DS, Simons M. Outcome measures in angiogenesis and laser trials: Natural history of no-option patients with ischemic heart disease who are not candidates for PTCA or CABG and who remain symptomatic on medical therapy. JACC 2001; 37: 7A. To be presented at the 50th Annual meeting of the American College of Cardiology, Orlando FL March 18-21, 2001.
26. Laham RJ, Post MJ, Sellke FW, Simons M. Tissue and myocardial distribution of endocardial vs epicardial intramyocardial delivery of 125-I-labeled basic fibroblast growth factor (bFGF): Is epicardial delivery obsolete. JACC 2001; 37: 227A. To be presented at the 50th Annual meeting of the American College of Cardiology, Orlando FL March 18-21, 2001.
Books:
1. Surgery of the Chest. Seventh Edition, Harcourt Health Sciences, Philadelphia
PA,
designated Editor in Chief.
Book Chapters, Reviews, and Invited Commentaries:
1. Harrison D, Minor R, Guerra R, Quillen J, Sellke FW. Endothelial dysfunction in atherosclerosis. In: Rubanyi GM (ed). Cardiovascular significance of endothelium-derived vasoactive factors. Futura Publishing 1991:263-280.
2. Wang SY, Friedman M, Johnson RG, Sellke FW. Coronary microvascular b-adrenoceptor subtypes and crystalloid cardioplegia. The Resistance Arteries: Integration of the Regulatory Pathways. Halpern, Bevan, Brayden et al (eds). Humana Press, 1994, p 357-364.
3. Sellke FW. Esophageal perforation and mediastinitis. In: Rippe, Irwin, Fink, Cerra, (eds). Intensive care medicine. 3rd Edition. Little, Brown, and Company, 1996, p 1841-1846.
4. Sellke FW. Cardioplegia and endothelium. Proceedings of the Actualities de Recherche Clinique de l'Hopital Broussais. In: Vasoreactivity of human vessels. J-N Fabiani, M Yacoub, A Carpentier (eds). Arnette Blackwell, 1996, p 163-178.
5. Sellke FW. Microvascular dysfunction following global ischemia and reperfusion. In: Haunso, Aldershvile, Svendsen, (eds). Coronary microcirculation during ischemia and reperfusion. Munkgaard International Publishers, Ltd. 1996, p 422-435.
6. Sellke FW, Boyle EM, Verrier ED. The pathophysiology of vasomotor dysfunction. Ann Thoracic Surg 1997; 64 (Suppl): S9-S15.
7. Selllke FW. Invited commentary. Ann Thorac Surg 1998; 66: 492.
8. Sellke FW. Invited commentary, Gene transfer for myocardial protection - A role in cardiovascular surgery? Circulation Surgical Issue 1998; 98: II-260 - 261.
9. Sellke FW. The pathophysiology of microvascular dysfunction after cardiovascular surgery. Current Topics in Pharmacology 1998; 4: 135-141.
10. Sellke FW, Harrison DG. The coronary microcirculation and angiogenesis. In: Cardiovascular angiogenesis, JA Ware, M Simons (ed.) 1999, New York, Oxford University Press. p. 258-288.
11. Sellke FW. Invited commentary: The role of cyclooxygenase in regulation of vascular tone during endotoxemia. Shock. Molecular, Cellular and Systemic Pathobiological Aspects and Therapeutic Approaches. 1999; 11: 443-444.
12. Sellke FW, Simons M. Leading Article. Angiogenesis in cardiovascular disease: Current status and potential. Drugs. Auckland, Adis International. 1999; 58: 391-196.
13. Sellke FW. Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: Roles of nitric oxide synthase and cyclooxygenase. Brazilian Journal of Medical and Biological Research 1999; 32: 1345-1352.
14. Sellke FW. Invited commentary. Ann Thorac Surg 2000; 69: 1161.
15. Simons M, Laham RJ, Post M, Sellke FW. Leading Article. Therapeutic angiogenesis: Potential role of basic fibroblast growth factor in patients with severe ischemic heart disease. Bio-drugs 2000; 14(1): 13-20.
16. Laham RJ, Post MJ, Sellke FW, Simons M. Therapeutic angiogenesis using local perivascular and pericardial delivery. Current interventional cardiology reports. 2000; 2: 213-217.
17. Post MJ, Laham RJ, Sellke FW, Simons M. Therapeutic angiogenesis in cardiology with protein formulations. Cardiovasc Res 2001; 49: 522-531.
18. Laham RJ, Simons M, Sellke FW. Gene Transfer for Angiogenesis in coronary artery disease. Ann Rev Internal Medicine 2001; 52: 485-502.
Internet Reviews and Commentaries and Taped Interviews
1. Sellke FW. Invited internet review (Cardiovascular Research): Goodwin et al. Coronary vasoconstriction to endothelin-1 increases with age before and after ischemia and reperfusion. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1 (No. 2): 5.
2. Sellke FW, Hutter AM. Surgical Angiogenesis with bFGF and VEGF. ACCEL, Sylvan Weinberg, Editor. Vol. 31, No. 1, 1999.
3. Sellke FW. Invited internet review (Cardiovascular Research): Lopez et al. VEGF administration in chronic myocardial ischemia. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1 (No. 4): 7.
4. Sellke FW. Invited internet review (Cardiovascular Research): Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1 (No. 4): 8.
5. Sellke FW. Update in techniques of myocardial revascularization: Therapeutic angiogenesis. First Virtual Congress of Cardiology. Argentina.
6. Sellke FW. Invited internet review (Ann Thorac Surg): Avoiding cardiopulmonary bypass in multivessel CABG reduces cytokine response and myocardial injury. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1: 6
7. Sellke FW. Invited internet review (Ann Surg): Organ preservation solutions increase endothelial permeability and promote loss of junctional proteins. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1: 7.
8. Sellke FW. Invited internet review (Circulation): Angiogenesis gene therapy. Phase I assessment of direct intramyocardial administration of an adenoviral vector expressing VEGF 121 cDNA to individuals with clinically significant severe coronary artery disease. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1: 8.
9. Sellke FW. Invited internet review (Cardiovascular Research): Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effects on myocardial angiogenesis. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1: 9.
10. Sellke FW. Invited internet review (Cardiovascular Research): Transmyocardial laser revascularization limits in vivo adenoviral-mediated gene transfer in porcine myocardium. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 1: 1.
11. Sellke FW. Invited internet review (Cardiovascular Research): Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition. Internet Cardiothoracic Digest. CME Network, Southampton, NY, A Wechsler, Ed. 1999, 2: 2.
12. Sellke FW. Invited internet review (Cardiovascular Research): Perioperative myocardial tissue injury and the release of inflammatory mediators in coronary artery bypass graft patients. Internet Cardiothoracic Digest. CME Network, Southampton, NY, L Cohn, Ed. 2000, 2: 3.
13. Sellke FW. Invited internet review (Cardiovascular Research): Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Internet Cardiothoracic Digest. CME Network, Southampton, NY, L Cohn, Ed. 2000, 2: 5.
14. Sellke FW. Invited internet review (Ann Thorac Surg): Angiogenesis in ischemic human myocardium: Clinical results after 3 years. Internet Cardiothoracic Digest. CME Network, Southampton, NY, L Cohn, Ed. 2000, 2: 7.
15. Sellke FW. Invited internet review (Journal of Thoracic and Cardiovascular Surgery): An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation. Internet Cardiothoracic Digest. CME Network, Southampton, NY, L Cohn, Ed. 2000, 2: 9.
16. Sellke FW. Invited internet review (Annals of Thoracic Surgery): Effect of induction and reperfusion with warm substrate-enriched cardioplegia on ventricular function. Internet Cardiothoracic Digest. CME Network, Southampton, NY, L Cohn, Ed. 2000, 2: 12.
17. Sellke FW, Harrison DG. The coronary microcirculation: Physiology. UpToDate (in press)
18. Sellke FW, Harrison DG. The coronary microcirculation in disease states. UpToDate (in press)